This project centres around developing the OpenScope microscope field-use, for example in testing blood and water samples. This project is likely to be carried out with some collaboration with the WaterScope team (developing a water quality testing kit for South Asia).
The requirements for the microscope are that it is robust, easy to use and set-up, and performs a very specific task reliably and effectively. The prototype microscope developed by the 2015 iGEM team will be taken as a starting point, but needs to be significantly modified.
Design of a 3D-printed chassis including sample holder (stage), mount for optics system and housing for the electronic components
Design of manually- and motor-controlled axis systems (x,y and z) on the chassis, and integration of the motors. The motorised systems must give smooth and reliable movement
Development and optimisation of software for motor control, image capture and analysis. This could include integration of a smartphone app with the microscope controls
Optimisation of the electronics for axis control and sample illumination. This is likely to be based on Raspberry Pi (computer) and Arduino (micro-controller) platforms
Optimisation of the optical pathway including choosing appropriate lenses, sample illumination and integration of the digital camera
Prototype testing through imaging of real-world biological samples
Comprehensive hardware documentation so that other groups can reproduce the product easily